I don't think this helped...but........

The few times that I have moteled it with the bags, it was a PITA getting them on/off the bike and schelping them in/out of the motel. All my soft bags except one shipped rain. Thus a rainproof liner (read; trash bag, zip-loc, etc) was necessary. If you are going to be toting your gear through motels, it is well worth the effort to get some bag liners with handles. If you have access to a sewing machine, you can make your own. Otherwise your local seamstress, upholstry shop, car seat guy, boat cover guy, etc will whip up whatever you need. Soft bags usually have a bunch of tie-down points. Getting them strapped on usually results in a bunch of straps trailing through the motel lobby when you bring them inside. As bad as that is, leaving the bags on the bike and checking in with the trash bag liners aint the soul of propriety. Sole of propriety is more like it. Recently i have been using cheap nylon gym-type bags as liners. That works ok for me as my ego was destroyed years ago. You may still be trying to have a decent self image.

I have dry bag saddle bags from riderwearhouse.com.  Ortlieb makes them. They aint cheap. Reflective material patches fore&aft mean that I dont have to be carefull how I throw them over the seat. Unless my mounting straps only fit one way. I was interested in the conspicuity of the yellow. All black is available. The yellow bags on my black bike are truely hidious. Hideous works for me as no one will ever come near enough to bother me or my gear. The bags are DRY.  No frog-strangling downpour, or all day soaking rain ever got past the bag. I haven't immersed them in a river crossing or a flooded underpass yet. So I dont know how that would fair. The bags come with a bit of plastic to help shape. It can be dispensed with if you need to compress your gear with some bungees. Note: bag closure takes some time to get used to.

Every cheap soft bag kept my gear together. But they might as well have been mesh bags for keeping my stuff dry and clean.

Years and years ago, I was dumpster diving and found 5-6 Pelican cases in nearly pristine condition. I didnt salvage/rescue them at the time because I didnt know what they were. Nor had I ever seen a set on a bike. Now that I know much much better. I have never found even one case since then.

If you dont travel in inclement weather, any dang bag will probably work ok.

You will get better suggestions if you post up how the bags will be used 90% of the time.

My next multi compartment tank bag system will probably be Ortlieb's waterproof tank bag. Ortlieb's dry saddle bags worked. And I will use them until I can get some hard cases to fit my budget.

I havent fallen on the bags. Yet. Crashing bags is a whole nother problem.

edit; A single dry duffle might be the best option. It has handles. Is usually easy to set up for fast bungee work including raincloth over the pillion/tailpiece. And can easily hold more stuff than two saddle bags with better access to all of it.

nobody rides half as well as they know how.